Association of lipid droplets accumulation with stemness and chemoresistance in pancreatic cancer

Association of lipid droplets accumulation with stemness and chemoresistance in pancreatic cancer

Association of lipid droplets accumulation with stemness and chemoresistance in pancreatic cancer 1125 1625 Metabolism & Cancer
3 Comments
  • Serena Castelli
    Serena C 27 May 2021 at 12 h 20 min

    Hi, congrats on the promising results. I’d like to ask if you have evaluated whether cancer cells use lipids deriving from OA treatment as mitochondrial fuel or they only accumulate lipid droplets. Is the cancer cells metabolism changed? Thanks

  • Alba Royo García
    Alba R 27 May 2021 at 14 h 26 min

    Thanks a lot for your comment!
    Yes, we are working on it, we have tested exogenous FAs treatment in combination with lipid metabolism inhibitors as Etomoxir, Ranolazine or Perhexiline. These treatments resulted in alterations in their metabolism because you are blocking FAO or lipid uptake, so they don’t metabolize more lipids and they accumulate it. This way, we are trying to study mitochondrial metabolism.
    I invite you to visit the poster called “Lipid Metabolism supports the tumorigenic potential of Pancreatic Cancer Stem Cells” from our group which is the second part of this study.

    Thanks again!

  • Serena Castelli
    Serena C 27 May 2021 at 16 h 51 min

    OK, thanks a lot for your explanation!

Comments are closed.

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